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Antimicrobial Agents and Chemotherapy, April 2005, p. 1354-1358, Vol. 49, No. 4
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.4.1354-1358.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Successive Emergence of Enterobacter aerogenes Strains Resistant to Imipenem and Colistin in a Patient

Aurélie Thiolas,1 Claude Bollet,1,{dagger} Bernard La Scola,2 Didier Raoult,2 and Jean-Marie Pagès1*

Enveloppe Bactérienne, Perméabilité et Antibiotiques, EA2197,1 Unité des Rickettsies, UMR6020-CNRS, IFR48, Faculté de Médecine, Université de la Méditerranée, Marseille, France2

Received 5 April 2004/ Returned for modification 26 July 2004/ Accepted 28 November 2004

Enterobacter aerogenes is an agent of hospital-acquired infection that exhibits a remarkable resistance to ß-lactam antibiotics during therapy. Five successive isolates of E. aerogenes infecting a patient and exhibiting a multiresistance phenotype to ß-lactam antibiotics and fluoroquinolones were investigated. Among these clinical strains, four presented resistant phenotypes during successive imipenem and colistin treatments. The involved resistance mechanisms exhibited by the successive isolates were associated with alterations of the outer membrane that caused a porin decrease and lipopolysaccharide modifications.

* Corresponding author. Mailing address: EA2197, Faculté de Médecine, 27 Blvd. Jean Moulin, 13385 Marseille Cedex 05, France. Phone: (33) 4 91 32 45 29. Fax: (33) 4 91 32 46 06. E-mail: Jean-Marie.Pages{at}medecine.univ-mrs.fr.

{dagger} Deceased.

Antimicrobial Agents and Chemotherapy, April 2005, p. 1354-1358, Vol. 49, No. 4
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.4.1354-1358.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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