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Antimicrobial Agents and Chemotherapy, April 2005, p. 1652-1655, Vol. 49, No. 4
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.4.1652-1655.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

In Vitro and In Vivo Cytotoxicities and Antileishmanial Activities of Thymol and Hemisynthetic Derivatives

Programa de Estudio y Control de Enfermedades Tropicales PECET,¹ Grupo de Investigación en Sustancias Bioactivas GISB, Universidad de Antioquia, Medellín, Colombia²

Received 25 November 2004/ Returned for modification 27 November 2004/ Accepted 29 November 2004

The in vitro and in vivo antileishmanial and cytotoxic activities of thymol and structural derivatives in comparison to those of Glucantime were studied. The results showed here suggest that thymol and hemisynthetic derivatives have promising antileishmanial potential and could be considered as new lead structures in the search for novel antileishmanial drugs.

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