This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Google Scholar Articles by Wang, G. Articles by Buckheit, R. W. PubMed PubMed Citation Articles by Wang, G. Articles by Buckheit, R. W., Jr.

 Previous Article  |  Next Article 

Antimicrob. Agents Chemother. doi:10.1128/AAC.00452-08
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Anti-HIV-1 Activity of Antimicrobial Peptides Derived from Human and Bovine Cathelicidins

The Structure-Fun Laboratory, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198; ImQuest BioSciences, Inc., 7340 Executive Way, Suite R, Frederick, MD 21704

^* To whom correspondence should be addressed. Email: gwang{at}unmc.edu.

	Abstract

From 15 human cathelicidin LL-37-derived peptides, FK-13 was identified as the smallest HIV-active peptide and GI-20 had the highest therapeutic index twice that of LL-37. BMAP-18 derived from bovine cathelicidin BMAP-27 possesses a similar therapeutic index to GI-20. Peptide sequence order, helical structures and aromatic residues are important in HIV inhibition.