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Antimicrob. Agents Chemother. doi:10.1128/AAC.00493-08
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

The KQ element, a complex genetic region conferring transferable resistance to carbapenems, aminoglycosides and fluoroquinolones in Klebsiella pneumoniae

From the Medical Service, 111(W), Louis Stokes Cleveland VA Medical Center and the Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio

^* To whom correspondence should be addressed. Email: louis.rice{at}va.gov.

	Abstract

The bla_KPC-3 and qnrB19 determinants of transferable Klebsiella pneumoniae plasmid pLRM24 reside within a complex region consisting of a Tn1331 backbone into which has inserted a Tn4401-like element and qnrB19 mobilized by an adjacent ISEcp1. This novel element represents a coalescence of genes conferring multidrug resistance in K. pneumoniae.