AAC Accepts, published online ahead of print on 19 October 2009
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Antimicrob. Agents Chemother. doi:10.1128/AAC.00714-09
Copyright (c) 2009, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

In Vitro Activity of Thimerosal against Ocular Pathogenic Fungi

Yan Xu*, Guangren Pang, Dongqing Zhao, Chuanwen Gao, Lutan Zhou, Shengtao Sun, and Bingliang Wang

Henan Eye Institute, Department of Ophthalmology, Henan Provincial People's Hospital, Zhengzhou, China; and Anyang Eye Hospital, Anyang, China

* To whom correspondence should be addressed. Email: xuyan990301{at}yahoo.com.cn.


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Abstract

The in vitro activity of thimerosal vs amphotericin B and natamycin was assessed against 244 ocular fungal isolates. The activity of thimerosal against Fusarium spp., Aspergillus spp. and Alternaria alternata was 256 times, 512 times and 128 times, respectively, greater than that of natamycin, 64 times, 32 times and 32 times, respectively, greater than amphotericin. Thimerosal's antifungal activity was significantly superior to those of amphotericin B and natamycin against ocular pathogenic fungi in vitro.