AAC Accepts, published online ahead of print on 2 November 2009
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Antimicrob. Agents Chemother. doi:10.1128/AAC.01168-09
Copyright (c) 2009, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Biologic Activities of the TolC-like Protein of Neisseria meningitidis as Assessed by Functional Complementation in Escherichia coli

Nazia Kamal and William M. Shafer*

Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322; and Laboratory of Bacterial Pathogenesis and Antimicrobial Resistance, VA Medical Center, Decatur, Georgia 30033

* To whom correspondence should be addressed. Email: wshafer{at}emory.edu.


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Abstract

Neisseria meningitidis can produce a TolC-like protein needed for secretion of FrpC, but not efflux of antimicrobials. We now report that expression of the meningococcal tolC gene in a TolC-deficient strain of Escherichia coli can restore properties of {alpha}-hemolysis and antimicrobial resistance known to involve efflux pumps.






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