AAC Accepts, published online ahead of print on 19 October 2009

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Antimicrob. Agents Chemother. doi:10.1128/AAC.01339-08
Copyright (c) 2009, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Assessment of the In-vitro Kinetic Activity of Caspofungin against Candida glabrata

V. NAGAPPAN, D. BOIKOV, and J. A. VAZQUEZ^*

Oakwood Hospital, Dearborn, MI; Henry Ford Hospital, Detroit, MI; Wayne State University School of Medicine, Detroit, MI

^* To whom correspondence should be addressed. Email: jvazque1{at}hfhs.org.

Echinocandins have become the drug of choice in infections due to Candida glabrata. The objective was to evaluate the in vitro activity of caspofungin alone and in combination against C. glabrata. In vitro assays demonstrated that caspofungin alone showed excellent fungicidal activity against C. glabrata, including fluconazole-resistant strains. The combination of caspofungin/azoles showed potential synergy against C. glabrata. Overall, caspofungin demonstrated excellent in vitro activity alone and in combination against strains of C. glabrata.