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Antimicrob. Agents Chemother. doi:10.1128/AAC.01599-07
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

The effects of sub-inhibitory concentrations of antibiotics on SOS and DNA repair gene expression in Staphylococcus aureus

Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada

^* To whom correspondence should be addressed. Email: mesak{at}interchange.ubc.ca.

	Abstract

SOS and DNA repair-associated promoter-lux reporter clones of Staphylococcus aureus were constructed to study the effects of sub-MIC of antibiotics on the transcription of the SOS and methyl mismatch repair (MMR) genes. Fluoroquinolones (FQ) upmodulated both SOS and MMR genes. Patterns of antibiotic-induced transcriptional modulation were altered in FQ-resistant mutants.