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Antimicrob. Agents Chemother. doi:10.1128/AAC.01656-07
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Reduced Biocide Susceptibility in Candida albicans Biofilms

University of Wisconsin, Dept of Medicine, Medical Microbiology and Immunology, Cellular and Molecular Biology, 600 Highland Ave, H4/572 Clinical Sciences Center, Madison WI 53792

^* To whom correspondence should be addressed. Email: dra{at}medicine.wisc.edu.

	Abstract

Candida biofilm formation is common during infection and environmental growth. We tested the impact of three biocides (EtOH, H₂O₂, and SDS) on C. albicans, C. parapsilosis, and C. glabrata biofilms. Efficacy required higher concentrations than planktonic controls. Combination study of two biocides (EtOH and H₂O₂) and fluconazole, demonstrated enhanced efficacy.