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Antimicrobial Agents and Chemotherapy, March 2005, p. 1222-1224, Vol. 49, No. 3
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.3.1222-1224.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Potential Clindamycin Resistance in Clindamycin-Susceptible, Erythromycin-Resistant Staphylococcus aureus: Report of a Clinical Failure

Temple University School of Medicine, Philadelphia, Pennsylvania¹

Received 25 June 2004/ Returned for modification 3 October 2004/ Accepted 4 November 2004

The erm gene product confers clindamycin resistance on Staphylococcus aureus. We report a clindamycin clinical failure where resistance developed on therapy in a D-test-positive strain. D tests of 91 clindamycin-susceptible, erythromycin-resistant S. aureus isolates showed that 68% of methicillin-susceptible and 12.3% of methicillin-resistant S. aureus strains were D-test positive.

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