AAC -- Table of Contents (May 1 2007, 51 [5])

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Contents: May 2007, Volume 51, Issue 5

       Mechanisms of Resistance

       Antiviral Agents

       Susceptibility

       Experimental Therapeutics

       Clinical Therapeutics

       Mechanisms of Action

       Analytical Procedures

       Biologic Response Modifiers

       Letters

       Errata

Other Issues

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To see an article, click its [Full Text], [Abstract] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

Mechanisms of Resistance:

Horizontal Gene Transfer of ftsI, Encoding Penicillin-Binding Protein 3, in Haemophilus influenzae
Sho Takahata, Takashi Ida, Nami Senju, Yumiko Sanbongi, Aiko Miyata, Kazunori Maebashi, and Shigeru Hoshiko
Antimicrob. Agents Chemother. May 2007 51: 1589-1595; published ahead of print February 26, 2007, doi:10.1128/AAC.01545-06
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Multiple Staphylococcal Cassette Chromosomes and Allelic Variants of Cassette Chromosome Recombinases in Staphylococcus aureus and Coagulase-Negative Staphylococci from Norway
Anne-Merethe Hanssen and Johanna U. Ericson Sollid
Antimicrob. Agents Chemother. May 2007 51: 1671-1677; published ahead of print February 16, 2007, doi:10.1128/AAC.00978-06
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Genetic Basis of Resistance to Fusidic Acid in Staphylococci
A. J. O'Neill, F. McLaws, G. Kahlmeter, A. S. Henriksen, and I. Chopra
Antimicrob. Agents Chemother. May 2007 51: 1737-1740; published ahead of print February 26, 2007, doi:10.1128/AAC.01542-06
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Tn1403, a Multiple-Antibiotic Resistance Transposon Made Up of Three Distinct Transposons
H. W. Stokes, Liam D. H. Elbourne, and Ruth M. Hall
Antimicrob. Agents Chemother. May 2007 51: 1827-1829; published ahead of print January 29, 2007, doi:10.1128/AAC.01279-06
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Clonal Spread of mef-Positive Macrolide-Resistant Streptococcus pneumoniae Isolates Causing Invasive Disease in Adults in Germany
Mark van der Linden, Adnan Al-Lahham, Stefan Haupts, and Ralf René Reinert
Antimicrob. Agents Chemother. May 2007 51: 1830-1834; published ahead of print February 26, 2007, doi:10.1128/AAC.01453-06
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Mutations in fusA Associated with Posttherapy Fusidic Acid Resistance in Clostridium difficile
T. Norén, T. Åkerlund, M. Wullt, L. G. Burman, and M. Unemo
Antimicrob. Agents Chemother. May 2007 51: 1840-1843; published ahead of print February 16, 2007, doi:10.1128/AAC.01283-06
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A Candida albicans Petite Mutant Strain with Uncoupled Oxidative Phosphorylation Overexpresses MDR1 and Has Diminished Susceptibility to Fluconazole and Voriconazole
Shaoji Cheng, Cornelius J. Clancy, Katherine T. Nguyen, William Clapp, and M. Hong Nguyen
Antimicrob. Agents Chemother. May 2007 51: 1855-1858; published ahead of print February 26, 2007, doi:10.1128/AAC.00182-07
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Two New dfr Genes in Trimethoprim-Resistant Integron-Negative Escherichia coli Isolates
M. Grape, L. Sundström, and G. Kronvall
Antimicrob. Agents Chemother. May 2007 51: 1863-1864; published ahead of print February 16, 2007, doi:10.1128/AAC.01273-06
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Tetracycline Resistance in Group A Streptococci: Emergence on a Global Scale and Influence on Multiple-Drug Resistance
Vanessa Ayer, Wezenet Tewodros, Anand Manoharan, Sini Skariah, Feng Luo, and Debra E. Bessen
Antimicrob. Agents Chemother. May 2007 51: 1865-1868; published ahead of print February 16, 2007, doi:10.1128/AAC.01341-06
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Dissemination of an Extended-Spectrum-β-Lactamase bla_TEM-52 Gene-Carrying IncI1 Plasmid in Various Salmonella enterica Serovars Isolated from Poultry and Humans in Belgium and France between 2001 and 2005
Axel Cloeckaert, Karine Praud, Benoît Doublet, Alessia Bertini, Alessandra Carattoli, Patrick Butaye, Hein Imberechts, Sophie Bertrand, Jean-Marc Collard, Guillaume Arlet, and François-Xavier Weill
Antimicrob. Agents Chemother. May 2007 51: 1872-1875; published ahead of print February 26, 2007, doi:10.1128/AAC.01514-06
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Acquired Echinocandin Resistance in a Candida krusei Isolate Due to Modification of Glucan Synthase
Jennifer Nielsen Kahn, Guillermo Garcia-Effron, Ming-Jo Hsu, Steven Park, Kieren A. Marr, and David S. Perlin
Antimicrob. Agents Chemother. May 2007 51: 1876-1878; published ahead of print February 26, 2007, doi:10.1128/AAC.00067-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antiviral Agents:

Addition of a C-Terminal Cysteine Improves the Anti-Herpes Simplex Virus Activity of a Peptide Containing the Human Immunodeficiency Virus Type 1 TAT Protein Transduction Domain
Hermann Bultmann, Jeremy Teuton, and Curtis R. Brandt
Antimicrob. Agents Chemother. May 2007 51: 1596-1607; published ahead of print January 29, 2007, doi:10.1128/AAC.01009-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Preclinical Safety Assessments of UC781 Anti-Human Immunodeficiency Virus Topical Microbicide Formulations
D. L. Patton, Y. T. Cosgrove Sweeney, J. E. Balkus, L. C. Rohan, B. J. Moncla, M. A. Parniak, and S. L. Hillier
Antimicrob. Agents Chemother. May 2007 51: 1608-1615; published ahead of print March 12, 2007, doi:10.1128/AAC.00984-06
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Comparison of the Phosphorylation of 4'-Ethynyl 2',3'-Dihydro-3'-Deoxythymidine with That of Other Anti-Human Immunodeficiency Virus Thymidine Analogs
Chih-Hung Hsu, Rong Hu, Ginger E. Dutschman, Guangwei Yang, Preethi Krishnan, Hiromichi Tanaka, Masanori Baba, and Yung-Chi Cheng
Antimicrob. Agents Chemother. May 2007 51: 1687-1693; published ahead of print March 12, 2007, doi:10.1128/AAC.01432-06
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Preclinical Testing of Candidate Topical Microbicides for Anti-Human Immunodeficiency Virus Type 1 Activity and Tissue Toxicity in a Human Cervical Explant Culture
James E. Cummins, Jr., Jeannette Guarner, Lisa Flowers, Patricia C. Guenthner, Jeanine Bartlett, Timothy Morken, Lisa A. Grohskopf, Lynn Paxton, and Charlene S. Dezzutti
Antimicrob. Agents Chemother. May 2007 51: 1770-1779; published ahead of print March 12, 2007, doi:10.1128/AAC.01129-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Direct Inactivation of Human Immunodeficiency Virus Type 1 by a Novel Small-Molecule Entry Inhibitor, DCM205
Yen T. Duong, D. Christopher Meadows, Indresh K. Srivastava, Jacquelyn Gervay-Hague, and Thomas W. North
Antimicrob. Agents Chemother. May 2007 51: 1780-1786; published ahead of print February 16, 2007, doi:10.1128/AAC.01001-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Selective Phosphorylation of Antiviral Drugs by Vaccinia Virus Thymidine Kinase
Mark N. Prichard, Kathy A. Keith, Mary P. Johnson, Emma A. Harden, Alexis McBrayer, Ming Luo, Shihong Qiu, Debasish Chattopadhyay, Xuesen Fan, Paul F. Torrence, and Earl R. Kern
Antimicrob. Agents Chemother. May 2007 51: 1795-1803; published ahead of print February 26, 2007, doi:10.1128/AAC.01447-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Compartmental Pharmacokinetic Analysis of Oral Amprenavir with Secondary Peaks
Olanrewaju Okusanya, Alan Forrest, Robin DiFrancesco, Sanela Bilic, Susan Rosenkranz, Michael F. Para, Elizabeth Adams, Kevin E. Yarasheski, Richard C. Reichman, Gene D. Morse and the ACTG 5043 Protocol Team
Antimicrob. Agents Chemother. May 2007 51: 1822-1826; published ahead of print February 5, 2007, doi:10.1128/AAC.00570-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Importance of Collection Tube during Clinical Studies of Oseltamivir
Niklas Lindegardh, Geraint R. Davies, Tran Tinh Hien, Jeremy Farrar, Pratap Singhasivanon, Nicholas P. J. Day, and Nicholas J. White
Antimicrob. Agents Chemother. May 2007 51: 1835-1836; published ahead of print February 26, 2007, doi:10.1128/AAC.01534-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Susceptibility of Drug-Resistant Clinical Herpes Simplex Virus Type 1 Strains to Essential Oils of Ginger, Thyme, Hyssop, and Sandalwood
Paul Schnitzler, Christine Koch, and Jürgen Reichling
Antimicrob. Agents Chemother. May 2007 51: 1859-1862; published ahead of print March 12, 2007, doi:10.1128/AAC.00426-06
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Susceptibility:

In Vivo Efficacy of Anidulafungin and Caspofungin against Candida glabrata and Association with In Vitro Potency in the Presence of Sera
Nathan P. Wiederhold, Laura K. Najvar, Rosie Bocanegra, Destiny Molina, Marcos Olivo, and John R. Graybill
Antimicrob. Agents Chemother. May 2007 51: 1616-1620; published ahead of print February 16, 2007, doi:10.1128/AAC.00105-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of Various Antimicrobials Alone and in Combination with Tigecycline against Carbapenem-Intermediate or -Resistant Acinetobacter baumannii
Marc H. Scheetz, Chao Qi, John R. Warren, Michael J. Postelnick, Teresa Zembower, Arlene Obias, and Gary A. Noskin
Antimicrob. Agents Chemother. May 2007 51: 1621-1626; published ahead of print February 16, 2007, doi:10.1128/AAC.01099-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Role of Acidic pH in the Susceptibility of Intraphagocytic Methicillin-Resistant Staphylococcus aureus Strains to Meropenem and Cloxacillin
Sandrine Lemaire, Françoise Van Bambeke, Marie-Paule Mingeot-Leclercq, Youri Glupczynski, and Paul M. Tulkens
Antimicrob. Agents Chemother. May 2007 51: 1627-1632; published ahead of print February 16, 2007, doi:10.1128/AAC.01192-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Expression and Purification of an Active Form of the Mycobacterium leprae DNA Gyrase and Its Inhibition by Quinolones
Stéphanie Matrat, Stéphanie Petrella, Emmanuelle Cambau, Wladimir Sougakoff, Vincent Jarlier, and Alexandra Aubry
Antimicrob. Agents Chemother. May 2007 51: 1643-1648; published ahead of print February 26, 2007, doi:10.1128/AAC.01282-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

National Survey on the Susceptibility of Bacteroides fragilis Group: Report and Analysis of Trends in the United States from 1997 to 2004
D. R. Snydman, N. V. Jacobus, L. A. McDermott, R. Ruthazer, Y. Golan, E. J. C. Goldstein, S. M. Finegold, L. J. Harrell, D. W. Hecht, S. G. Jenkins, C. Pierson, R. Venezia, V. Yu, J. Rihs, and S. L. Gorbach
Antimicrob. Agents Chemother. May 2007 51: 1649-1655; published ahead of print February 5, 2007, doi:10.1128/AAC.01435-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effect of Macrolide Usage on Emergence of Erythromycin-Resistant Campylobacter Isolates in Chickens
Jun Lin, Meiguan Yan, Orhan Sahin, Sonia Pereira, Yun-Juan Chang, and Qijing Zhang
Antimicrob. Agents Chemother. May 2007 51: 1678-1686; published ahead of print March 12, 2007, doi:10.1128/AAC.01411-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antiplasmodial Activity of Lauryl-Lysine Oligomers
I. Radzishevsky, M. Krugliak, H. Ginsburg, and A. Mor
Antimicrob. Agents Chemother. May 2007 51: 1753-1759; published ahead of print February 16, 2007, doi:10.1128/AAC.01288-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of Isavuconazole and Other Antifungal Agents against Candida Bloodstream Isolates
H. Seifert, U. Aurbach, D. Stefanik, and O. Cornely
Antimicrob. Agents Chemother. May 2007 51: 1818-1821; published ahead of print February 16, 2007, doi:10.1128/AAC.01217-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efficacy of the De Novo-Derived Antimicrobial Peptide WLBU2 against Oral Bacteria
Karen F. Novak, William J. Diamond, Sreenatha Kirakodu, Rebecca Peyyala, Kimberly W. Anderson, Ronald C. Montelaro, and Timothy A. Mietzner
Antimicrob. Agents Chemother. May 2007 51: 1837-1839; published ahead of print February 26, 2007, doi:10.1128/AAC.00924-06
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In Vitro Activities of Isepamicin, Other Aminoglycosides, and Capreomycin against Clinical Isolates of Rapidly Growing Mycobacteria in Taiwan
Gwan-Han Shen, Bo-Da Wu, Kun-Ming Wu, and Jiann-Hwa Chen
Antimicrob. Agents Chemother. May 2007 51: 1849-1851; published ahead of print March 12, 2007, doi:10.1128/AAC.01551-06
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Artemisinins Inhibit Trypanosoma cruzi and Trypanosoma brucei rhodesiense In Vitro Growth
Yuliya V. Mishina, Sanjeev Krishna, Richard K. Haynes, and John C. Meade
Antimicrob. Agents Chemother. May 2007 51: 1852-1854; published ahead of print March 5, 2007, doi:10.1128/AAC.01544-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Candida albicans and Candida dubliniensis Respond Differently to Echinocandin Antifungal Agents In Vitro
Mette D. Jacobsen, Julie A. Whyte, and Frank C. Odds
Antimicrob. Agents Chemother. May 2007 51: 1882-1884; published ahead of print February 16, 2007, doi:10.1128/AAC.01525-06
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Experimental Therapeutics:

In Vivo Pharmacodynamic Activity of the Glycopeptide Dalbavancin
David Andes and William A. Craig
Antimicrob. Agents Chemother. May 2007 51: 1633-1642; published ahead of print February 16, 2007, doi:10.1128/AAC.01264-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Comparative Activities of Daptomycin, Linezolid, and Tigecycline against Catheter-Related Methicillin-Resistant Staphylococcus Bacteremic Isolates Embedded in Biofilm
Issam Raad, Hend Hanna, Ying Jiang, Tanya Dvorak, Ruth Reitzel, Gassan Chaiban, Robert Sherertz, and Ray Hachem
Antimicrob. Agents Chemother. May 2007 51: 1656-1660; published ahead of print March 12, 2007, doi:10.1128/AAC.00350-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Single-Dose Oral Amoxicillin or Linezolid for Prophylaxis of Experimental Endocarditis Due to Vancomycin-Susceptible and Vancomycin-Resistant Enterococcus faecalis
Philippe Moreillon, Walter R. Wilson, Roland Leclercq, and José M. Entenza
Antimicrob. Agents Chemother. May 2007 51: 1661-1665; published ahead of print March 12, 2007, doi:10.1128/AAC.00744-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

EDP-420, a Bicyclolide (Bridged Bicyclic Macrolide), Is Active against Mycobacterium avium
Luiz E. Bermudez, Nima Motamedi, Christopher Chee, Gyulnar Baimukanova, Peter Kolonoski, Clark Inderlied, Priscilla Aralar, Guoqiang Wang, Ly Tam Phan, and Lowell S. Young
Antimicrob. Agents Chemother. May 2007 51: 1666-1670; published ahead of print February 12, 2007, doi:10.1128/AAC.01303-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Roxithromycin Favorably Modifies the Initial Phase of Resistance against Infection with Macrolide-Resistant Streptococcus pneumoniae in a Murine Pneumonia Model
Yasuki Yasuda, Kei Kasahara, Fumiko Mizuno, Kazuyuki Nishi, Keiichi Mikasa, and Eiji Kita
Antimicrob. Agents Chemother. May 2007 51: 1741-1752; published ahead of print March 12, 2007, doi:10.1128/AAC.01459-06
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Rapid Bactericidal Activity of Daptomycin against Methicillin-Resistant and Methicillin-Susceptible Staphylococcus aureus Peritonitis in Mice as Measured with Bioluminescent Bacteria
Lawrence I. Mortin, Tongchuan Li, Andrew D. G. Van Praagh, Shuxin Zhang, Xi-Xian Zhang, and Jeff D. Alder
Antimicrob. Agents Chemother. May 2007 51: 1787-1794; published ahead of print February 16, 2007, doi:10.1128/AAC.00738-06
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Clinical Therapeutics:

Activities of Amodiaquine, Artesunate, and Artesunate-Amodiaquine against Asexual- and Sexual-Stage Parasites in Falciparum Malaria in Children
Akintunde Sowunmi, Tunde Balogun, Grace O. Gbotosho, Christian T. Happi, Ahmed A. Adedeji, and Fatai A. Fehintola
Antimicrob. Agents Chemother. May 2007 51: 1694-1699; published ahead of print February 26, 2007, doi:10.1128/AAC.00077-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Clinical Pharmacodynamics of Meropenem in Patients with Lower Respiratory Tract Infections
Chonghua Li, Xiaoli Du, Joseph L. Kuti, and David P. Nicolau
Antimicrob. Agents Chemother. May 2007 51: 1725-1730; published ahead of print February 16, 2007, doi:10.1128/AAC.00294-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Randomized Controlled Trial of Fosmidomycin-Clindamycin versus Sulfadoxine-Pyrimethamine in the Treatment of Plasmodium falciparum Malaria
Sunny Oyakhirome, Saadou Issifou, Peter Pongratz, Fortune Barondi, Michael Ramharter, Jürgen F. Kun, Michel A. Missinou, Bertrand Lell, and Peter G. Kremsner
Antimicrob. Agents Chemother. May 2007 51: 1869-1871; published ahead of print February 26, 2007, doi:10.1128/AAC.01448-06
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Mechanisms of Action:

Immunomodulatory Peptide from Cystatin, a Natural Cysteine Protease Inhibitor, against Leishmaniasis as a Model Macrophage Disease
Snigdha Mukherjee, Anindita Ukil, and Pijush K. Das
Antimicrob. Agents Chemother. May 2007 51: 1700-1707; published ahead of print March 5, 2007, doi:10.1128/AAC.01555-06
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Evaluation of the metS and murB Loci for Antibiotic Discovery Using Targeted Antisense RNA Expression Analysis in Bacillus anthracis
G. C. Kedar, Vickie Brown-Driver, Daniel R. Reyes, Mark T. Hilgers, Mark A. Stidham, Karen Joy Shaw, John Finn, and Robert J. Haselbeck
Antimicrob. Agents Chemother. May 2007 51: 1708-1718; published ahead of print March 5, 2007, doi:10.1128/AAC.01180-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Covalent Dimer Species of β-Defensin Defr1 Display Potent Antimicrobial Activity against Multidrug-Resistant Bacterial Pathogens
Karen Taylor, Bryan McCullough, David J. Clarke, Ross J. Langley, Tali Pechenick, Adrian Hill, Dominic J. Campopiano, Perdita E. Barran, Julia R. Dorin, and John R. W. Govan
Antimicrob. Agents Chemother. May 2007 51: 1719-1724; published ahead of print March 12, 2007, doi:10.1128/AAC.01531-06
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Role of Homoserine Transacetylase as a New Target for Antifungal Agents
Ishac Nazi, Adam Scott, Anita Sham, Laura Rossi, Peter R. Williamson, James W. Kronstad, and Gerard D. Wright
Antimicrob. Agents Chemother. May 2007 51: 1731-1736; published ahead of print March 12, 2007, doi:10.1128/AAC.01400-06
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Defining the Molecular Forces That Determine the Impact of Neomycin on Bacterial Protein Synthesis: Importance of the 2'-Amino Functionality
Christopher M. Barbieri, Malvika Kaul, Melanie Bozza-Hingos, Fang Zhao, Yitzhak Tor, Thomas Hermann, and Daniel S. Pilch
Antimicrob. Agents Chemother. May 2007 51: 1760-1769; published ahead of print March 12, 2007, doi:10.1128/AAC.01267-06
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Asiatic Acid and Corosolic Acid Enhance the Susceptibility of Pseudomonas aeruginosa Biofilms to Tobramycin
Eliane Garo, Gary R. Eldridge, Matt G. Goering, Elinor DeLancey Pulcini, Martin A. Hamilton, John W. Costerton, and Garth A. James
Antimicrob. Agents Chemother. May 2007 51: 1813-1817; published ahead of print March 12, 2007, doi:10.1128/AAC.01037-06
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In Vitro Bactericidal Activity of the Antiprotozoal Drug Miltefosine against Streptococcus pneumoniae and Other Pathogenic Streptococci
Daniel Llull, Luis Rivas, and Ernesto García
Antimicrob. Agents Chemother. May 2007 51: 1844-1848; published ahead of print March 12, 2007, doi:10.1128/AAC.01428-06
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Analytical Procedures:

Modeling the Combination of Amphotericin B, Micafungin, and Nikkomycin Z against Aspergillus fumigatus In Vitro Using a Novel Response Surface Paradigm
Yseult F. Brun, Carly G. Dennis, William R. Greco, Ralph J. Bernacki, Paula J. Pera, Jennifer J. Bushey, Richard C. Youn, Donald B. White, and Brahm H. Segal
Antimicrob. Agents Chemother. May 2007 51: 1804-1812; published ahead of print February 26, 2007, doi:10.1128/AAC.01007-06
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Biologic Response Modifiers:

Immunomodulatory Effects of Fosfomycin in Experimental Human Endotoxemia
Robert Sauermann, Claudia Marsik, Ilka Steiner, Katja Seir, Tuende Cvitko, Markus Zeitlinger, Oswald Wagner, and Christian Joukhadar
Antimicrob. Agents Chemother. May 2007 51: 1879-1881; published ahead of print March 12, 2007, doi:10.1128/AAC.00914-06
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Letters:

Molecular Epidemiology of Telithromycin-Resistant Pneumococci in Finland
Merja Rantala, Sofia Nyberg, Marianne Lindgren, Pentti Huovinen, Jari Jalava, Reetta Skyttä, Laura Teirilä, Anni Vainio, Anni Virolainen-Julkunen, and Tarja Kaijalainen
Antimicrob. Agents Chemother. May 2007 51: 1885-1887; published ahead of print February 26, 2007, doi:10.1128/AAC.00187-07
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Errata:

New Small-Molecule Synthetic Antimycobacterials
Lluis Ballell, Robert A. Field, Ken Duncan, and Robert J. Young
Antimicrob. Agents Chemother. May 2007 51: 1888
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To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.