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Experimental Therapeutics:

K. Stepniewska and N. J. White

Pharmacokinetic Determinants of the Window of Selection for Antimalarial Drug Resistance
Antimicrob. Agents Chemother. 2008 52: 1589-1596. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Li-Yan Yin, Jason H. Calhoun, Jacob K. Thomas, Stuart Shapiro, and Anne Schmitt-Hoffmann

Efficacies of Ceftobiprole Medocaril and Comparators in a Rabbit Model of Osteomyelitis Due to Methicillin-Resistant Staphylococcus aureus
Antimicrob. Agents Chemother. 2008 52: 1618-1622. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Emir Hodzic, Sunlian Feng, Kevin Holden, Kimberly J. Freet, and Stephen W. Barthold

Persistence of Borrelia burgdorferi following Antibiotic Treatment in Mice
Antimicrob. Agents Chemother. 2008 52: 1728-1736. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Mario Faúndez, Rodrigo López-Muñoz, Gloria Torres, Antonio Morello, Jorge Ferreira, Ulrike Kemmerling, Myriam Orellana, and Juan D. Maya

Buthionine Sulfoximine Has Anti-Trypanosoma cruzi Activity in a Murine Model of Acute Chagas' Disease and Enhances the Efficacy of Nifurtimox
Antimicrob. Agents Chemother. 2008 52: 1837-1839. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Lee Ann Campbell, Cho-Chou Kuo, Robert J. Suchland, and David M. Rothstein

Efficacy of Benzoxazinorifamycins in a Mouse Model of Chlamydia pneumoniae Lung Infection
Antimicrob. Agents Chemother. 2008 52: 1855-1858. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Hiroshi Kakeya, Yoshitsugu Miyazaki, Hisato Senda, Tsutomu Kobayashi, Masafumi Seki, Koichi Izumikawa, Kazunori Yanagihara, Yoshihiro Yamamoto, Takayoshi Tashiro, and Shigeru Kohno

Efficacy of SPK-843, a Novel Polyene Antifungal, in Comparison with Amphotericin B, Liposomal Amphotericin B, and Micafungin against Murine Pulmonary Aspergillosis
Antimicrob. Agents Chemother. 2008 52: 1868-1870. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Hiroshi Kakeya, Yoshitsugu Miyazaki, Hisato Senda, Tsutomu Kobayashi, Masafumi Seki, Koichi Izumikawa, Yoshihiro Yamamoto, Kazunori Yanagihara, Takayoshi Tashiro, and Shigeru Kohno

Efficacy of SPK-843, a Novel Polyene Antifungal, in a Murine Model of Systemic Cryptococcosis
Antimicrob. Agents Chemother. 2008 52: 1871-1872. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Susceptibility:

Francis F. Arhin, Ingrid Sarmiento, Adam Belley, Geoffrey A. McKay, Deborah C. Draghi, Parveen Grover, Daniel F. Sahm, Thomas R. Parr, Jr., and Gregory Moeck

Effect of Polysorbate 80 on Oritavancin Binding to Plastic Surfaces: Implications for Susceptibility Testing
Antimicrob. Agents Chemother. 2008 52: 1597-1603. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Hayssam Khalil, Tao Chen, Renée Riffon, Rutao Wang, and Zhao Wang

Synergy between Polyethylenimine and Different Families of Antibiotics against a Resistant Clinical Isolate of Pseudomonas aeruginosa
Antimicrob. Agents Chemother. 2008 52: 1635-1641. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Laura Lawrence, Paul Danese, Joe DeVito, Francois Franceschi, and Joyce Sutcliffe

In Vitro Activities of the Rx-01 Oxazolidinones against Hospital and Community Pathogens
Antimicrob. Agents Chemother. 2008 52: 1653-1662. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

S. Grayo, O. Join-Lambert, M. C. Desroches, and A. Le Monnier

Comparison of the In Vitro Efficacies of Moxifloxacin and Amoxicillin against Listeria monocytogenes
Antimicrob. Agents Chemother. 2008 52: 1697-1702. [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]  

Aldona L. Baltch, William J. Ritz, Lawrence H. Bopp, Phyllis Michelsen, and Raymond P. Smith

Activities of Daptomycin and Comparative Antimicrobials, Singly and in Combination, against Extracellular and Intracellular Staphylococcus aureus and Its Stable Small-Colony Variant in Human Monocyte-Derived Macrophages and in Broth
Antimicrob. Agents Chemother. 2008 52: 1829-1833. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Chun-Ming Huang, Justin W. Torpey, Yu-Tseung Liu, Yun-Ru Chen, Katherine E. Williams, Elizabeth A. Komives, and Richard L. Gallo

A Peptide with a ProGln C Terminus in the Human Saliva Peptidome Exerts Bactericidal Activity against Propionibacterium acnes
Antimicrob. Agents Chemother. 2008 52: 1834-1836. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Patricia J. Baudry, Kim Nichol, Melanie DeCorby, Laura Mataseje, Michael R. Mulvey, Daryl J. Hoban, and George G. Zhanel

Comparison of Antimicrobial Resistance Profiles among Extended-Spectrum-β-Lactamase-Producing and Acquired AmpC β-Lactamase-Producing Escherichia coli Isolates from Canadian Intensive Care Units
Antimicrob. Agents Chemother. 2008 52: 1846-1849. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Lodewijk Spanjaard and Christina M. J. E. Vandenbroucke-Grauls

Activity of Daptomycin against Listeria monocytogenes Isolates from Cerebrospinal Fluid
Antimicrob. Agents Chemother. 2008 52: 1850-1851. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Susanne Perkhofer, Daniel Jost, Manfred P. Dierich, and Cornelia Lass-Flörl

Susceptibility Testing of Anidulafungin and Voriconazole Alone and in Combination against Conidia and Hyphae of Aspergillus spp. under Hypoxic Conditions
Antimicrob. Agents Chemother. 2008 52: 1873-1875. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Kerstin Hinrichsen, Rainer Podschun, Sabine Schubert, Jens M. Schröder, Jürgen Harder, and Ehrhardt Proksch

Mouse Beta-Defensin-14, an Antimicrobial Ortholog of Human Beta-Defensin-3
Antimicrob. Agents Chemother. 2008 52: 1876-1879. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Antiviral Agents:

Matthew F. McCown, Sonal Rajyaguru, Sophie Le Pogam, Samir Ali, Wen-Rong Jiang, Hyunsoon Kang, Julian Symons, Nick Cammack, and Isabel Najera

The Hepatitis C Virus Replicon Presents a Higher Barrier to Resistance to Nucleoside Analogs than to Nonnucleoside Polymerase or Protease Inhibitors
Antimicrob. Agents Chemother. 2008 52: 1604-1612. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Aurélie Barrail-Tran, Laurence Morand-Joubert, Gwendoline Poizat, Gilles Raguin, Clotilde Le Tiec, François Clavel, Elisabeth Dam, Geneviève Chêne, Pierre-Marie Girard, Anne-Marie Taburet and the Puzzle-1 (ANRS 104) Study Group

Predictive Values of the Human Immunodeficiency Virus Phenotype and Genotype and of Amprenavir and Lopinavir Inhibitory Quotients in Heavily Pretreated Patients on a Ritonavir-Boosted Dual-Protease-Inhibitor Regimen
Antimicrob. Agents Chemother. 2008 52: 1642-1646. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Evan D. Kharasch, Darain Mitchell, Rebecka Coles, and Roberto Blanco

Rapid Clinical Induction of Hepatic Cytochrome P4502B6 Activity by Ritonavir
Antimicrob. Agents Chemother. 2008 52: 1663-1669. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Min Ji Kim, Claude Jardel, Cyrille Barthélémy, Véronique Jan, Jean Philippe Bastard, Sandrine Fillaut-Chapin, Sydney Houry, Jacqueline Capeau, and Anne Lombès

Mitochondrial DNA Content, an Inaccurate Biomarker of Mitochondrial Alteration in Human Immunodeficiency Virus-Related Lipodystrophy
Antimicrob. Agents Chemother. 2008 52: 1670-1676. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Robert Jordan, Deborah Tien, Tove' C. Bolken, Kevin F. Jones, Shanthakumar R. Tyavanagimatt, Josef Strasser, Annie Frimm, Michael L. Corrado, Phoebe G. Strome, and Dennis E. Hruby

Single-Dose Safety and Pharmacokinetics of ST-246, a Novel Orthopoxvirus Egress Inhibitor
Antimicrob. Agents Chemother. 2008 52: 1721-1727. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Natalia Teleshova, Theresa Chang, Albert Profy, and Mary E. Klotman

Inhibitory Effect of PRO 2000, a Candidate Microbicide, on Dendritic Cell-Mediated Human Immunodeficiency Virus Transfer
Antimicrob. Agents Chemother. 2008 52: 1751-1758. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Pin-Fang Lin, Beata Nowicka-Sans, Brian Terry, Sharon Zhang, Chunfu Wang, Li Fan, Ira Dicker, Volodymyr Gali, Helen Higley, Neil Parkin, Daniel Tenney, Mark Krystal, and Richard Colonno

Entecavir Exhibits Inhibitory Activity against Human Immunodeficiency Virus under Conditions of Reduced Viral Challenge
Antimicrob. Agents Chemother. 2008 52: 1759-1767. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Carol Lackman-Smith, Clay Osterling, Katherine Luckenbaugh, Marie Mankowski, Beth Snyder, Gareth Lewis, Jeremy Paull, Albert Profy, Roger G. Ptak, Robert W. Buckheit, Jr., Karen M. Watson, James E. Cummins, Jr., and Brigitte E. Sanders-Beer

Development of a Comprehensive Human Immunodeficiency Virus Type 1 Screening Algorithm for Discovery and Preclinical Testing of Topical Microbicides
Antimicrob. Agents Chemother. 2008 52: 1768-1781. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

D. Ronald Goldwater, Carolyn Dougherty, Mary Schumacher, and Stephen A. Villano

Effect of Ketoconazole on the Pharmacokinetics of Maribavir in Healthy Adults
Antimicrob. Agents Chemother. 2008 52: 1794-1798. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Stephen D. Woodhouse, Caroline Smith, Maud Michelet, Norica Branza-Nichita, Mark Hussey, Raymond A. Dwek, and Nicole Zitzmann

Iminosugars in Combination with Interferon and Ribavirin Permanently Eradicate Noncytopathic Bovine Viral Diarrhea Virus from Persistently Infected Cells
Antimicrob. Agents Chemother. 2008 52: 1820-1828. [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]  

David L. Wyles, Kelly A. Kaihara, and Robert T. Schooley

Synergy of a Hepatitis C Virus (HCV) NS4A Antagonist in Combination with HCV Protease and Polymerase Inhibitors
Antimicrob. Agents Chemother. 2008 52: 1862-1864. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Mechanisms of Resistance:

Laurent Poirel, Wejdene Mansour, Olfa Bouallegue, and Patrice Nordmann

Carbapenem-Resistant Acinetobacter baumannii Isolates from Tunisia Producing the OXA-58-Like Carbapenem-Hydrolyzing Oxacillinase OXA-97
Antimicrob. Agents Chemother. 2008 52: 1613-1617. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Javier Botet, María Rodríguez-Mateos, Juan P. G. Ballesta, José Luis Revuelta, and Miguel Remacha

A Chemical Genomic Screen in Saccharomyces cerevisiae Reveals a Role for Diphthamidation of Translation Elongation Factor 2 in Inhibition of Protein Synthesis by Sordarin
Antimicrob. Agents Chemother. 2008 52: 1623-1629. [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]  

Mark I. Garvey and Laura J. V. Piddock

The Efflux Pump Inhibitor Reserpine Selects Multidrug-Resistant Streptococcus pneumoniae Strains That Overexpress the ABC Transporters PatA and PatB
Antimicrob. Agents Chemother. 2008 52: 1677-1685. [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]  

Lisa K. Smith and Alexander S. Mankin

Transcriptional and Translational Control of the mlr Operon, Which Confers Resistance to Seven Classes of Protein Synthesis Inhibitors
Antimicrob. Agents Chemother. 2008 52: 1703-1712. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Keith Miller, Colin J. Dunsmore, Colin W. G. Fishwick, and Ian Chopra

Linezolid and Tiamulin Cross-Resistance in Staphylococcus aureus Mediated by Point Mutations in the Peptidyl Transferase Center
Antimicrob. Agents Chemother. 2008 52: 1737-1742. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Yu-Hong Min, Ae-Ran Kwon, Eun-Jeong Yoon, Mi-Ja Shim, and Eung-Chil Choi

Translational Attenuation and mRNA Stabilization as Mechanisms of erm(B) Induction by Erythromycin
Antimicrob. Agents Chemother. 2008 52: 1782-1789. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Doroti de Oliveira Garcia, Yohei Doi, Dora Szabo, Jennifer M. Adams-Haduch, Tânia M. I. Vaz, Daniela Leite, Maria Clara Padoveze, Maristela P. Freire, Fernanda P. Silveira, and David L. Paterson

Multiclonal Outbreak of Klebsiella pneumoniae Producing Extended-Spectrum β-Lactamase CTX-M-2 and Novel Variant CTX-M-59 in a Neonatal Intensive Care Unit in Brazil
Antimicrob. Agents Chemother. 2008 52: 1790-1793. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Nuno Mendonça, Vera Manageiro, Frédéric Robin, M. José Salgado, Eugénia Ferreira, Manuela Caniça, and Richard Bonnet

The Lys234Arg Substitution in the Enzyme SHV-72 Is a Determinant for Resistance to Clavulanic Acid Inhibition
Antimicrob. Agents Chemother. 2008 52: 1806-1811. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Thomas R. Fritsche, Mariana Castanheira, George H. Miller, Ronald N. Jones, and Eliana S. Armstrong

Detection of Methyltransferases Conferring High-Level Resistance to Aminoglycosides in Enterobacteriaceae from Europe, North America, and Latin America
Antimicrob. Agents Chemother. 2008 52: 1843-1845. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Pontus Juréen, Jim Werngren, Juan-Carlos Toro, and Sven Hoffner

Pyrazinamide Resistance and pncA Gene Mutations in Mycobacterium tuberculosis
Antimicrob. Agents Chemother. 2008 52: 1852-1854. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

K. Weber, R. Sohr, B. Schulz, M. Fleischhacker, and M. Ruhnke

Secretion of E,E-Farnesol and Biofilm Formation in Eight Different Candida Species
Antimicrob. Agents Chemother. 2008 52: 1859-1861. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Érica Lourenço da Fonseca, Fernanda dos Santos Freitas, José Carlos de Amorim, and Ana Carolina Paulo Vicente

Detection of New arr-4 and arr-5 Gene Cassettes in Clinical Pseudomonas aeruginosa and Klebsiella pneumoniae Strains from Brazil
Antimicrob. Agents Chemother. 2008 52: 1865-1867. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Sho Takahata, Yoshihisa Kato, Yumiko Sanbongi, Kazunori Maebashi, and Takashi Ida

Comparison of the Efficacies of Oral β-Lactams in Selection of Haemophilus influenzae Transformants with Mutated ftsI Genes
Antimicrob. Agents Chemother. 2008 52: 1880-1883. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Rawya S. Al-Dhaheri and L. Julia Douglas

Absence of Amphotericin B-Tolerant Persister Cells in Biofilms of Some Candida Species
Antimicrob. Agents Chemother. 2008 52: 1884-1887. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Hsiu-Mei Wu, Rajendra Prasad Janapatla, Yueh-Ren Ho, Kuei-Hsiang Hung, Chi-Wen Wu, Jing-Jou Yan, and Jiunn-Jong Wu

Emergence of Fluoroquinolone Resistance in Group B Streptococcal Isolates in Taiwan
Antimicrob. Agents Chemother. 2008 52: 1888-1890. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Pharmacology:

Ying Jun Cao, Charles W. Flexner, Shelia Dunaway, Jeong-Gun Park, Karin Klingman, Ilene Wiggins, Jeanne Conley, Christine Radebaugh, Angela D. Kashuba, Ron MacFarland, Stephen Becker, and Craig W. Hendrix

Effect of Low-Dose Ritonavir on the Pharmacokinetics of the CXCR4 Antagonist AMD070 in Healthy Volunteers
Antimicrob. Agents Chemother. 2008 52: 1630-1634. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Clinical Therapeutics:

Dean Scholl and David W. Martin, Jr.

Antibacterial Efficacy of R-Type Pyocins towards Pseudomonas aeruginosa in a Murine Peritonitis Model
Antimicrob. Agents Chemother. 2008 52: 1647-1652. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Peter Troke, Koldo Aguirrebengoa, Carmen Arteaga, David Ellis, Christopher H. Heath, Irja Lutsar, Montserrat Rovira, Quoc Nguyen, Monica Slavin, Sharon C. A. Chen on behalf of the Global Scedosporium Study Group

Treatment of Scedosporiosis with Voriconazole: Clinical Experience with 107 Patients
Antimicrob. Agents Chemother. 2008 52: 1743-1750. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Steffen Borrmann, Pierre-Blaise Matsiegui, Michel Anoumou Missinou, and Peter G. Kremsner

Effects of Plasmodium falciparum Parasite Population Size and Patient Age on Early and Late Parasitological Outcomes of Antimalarial Treatment in Children
Antimicrob. Agents Chemother. 2008 52: 1799-1805. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

John F. Mohr, III, Luis Ostrosky-Zeichner, David J. Wainright, Donald H. Parks, Timothy C. Hollenbeck, and Charles D. Ericsson

Pharmacokinetic Evaluation of Single-Dose Intravenous Daptomycin in Patients with Thermal Burn Injury
Antimicrob. Agents Chemother. 2008 52: 1891-1893. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Chemistry; Biosynthesis:

S. Eys, D. Schwartz, W. Wohlleben, and E. Schinko

Three Thioesterases Are Involved in the Biosynthesis of Phosphinothricin Tripeptide in Streptomyces viridochromogenes Tü494
Antimicrob. Agents Chemother. 2008 52: 1686-1696. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Mechanisms of Action:

Christoph Gelhaus, Thomas Jacobs, Jörg Andrä, and Matthias Leippe

The Antimicrobial Peptide NK-2, the Core Region of Mammalian NK-Lysin, Kills Intraerythrocytic Plasmodium falciparum
Antimicrob. Agents Chemother. 2008 52: 1713-1720. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Queenie C. K. Cheung, Patricia V. Turner, Cheng Song, De Wu, Hugh Y. Cai, Janet I. MacInnes, and Julang Li

Enhanced Resistance to Bacterial Infection in Protegrin-1 Transgenic Mice
Antimicrob. Agents Chemother. 2008 52: 1812-1819. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Lindi Roberts, Timothy J. Egan, Keith A. Joiner, and Heinrich C. Hoppe

Differential Effects of Quinoline Antimalarials on Endocytosis in Plasmodium falciparum
Antimicrob. Agents Chemother. 2008 52: 1840-1842. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Letters:

Alexandra Loli, Leonidas S. Tzouvelekis, Dimitra Gianneli, Eva Tzelepi, and Vivi Miriagou

Outbreak of Acinetobacter baumannii with Chromosomally Encoded VIM-1 Undetectable by Imipenem-EDTA Synergy Tests
Antimicrob. Agents Chemother. 2008 52: 1894-1896. [Full Text] [PDF] [Reprints and Permissions]  

Nuno Mendonça, Vera Manageiro, Richard Bonnet, and Manuela Caniça

Biochemical Characterization of SHV-55, an Extended-Spectrum Class A β-Lactamase from Klebsiella pneumoniae
Antimicrob. Agents Chemother. 2008 52: 1897-1898. [Full Text] [PDF] [Reprints and Permissions]  

Errata:

Edward P. Garvey, Brian A. Johns, Margaret J. Gartland, Scott A. Foster, Wayne H. Miller, Robert G. Ferris, Richard J. Hazen, Mark R. Underwood, Eric E. Boros, James B. Thompson, Jason G. Weatherhead, Cecilia S. Koble, Scott H. Allen, Lee T. Schaller, Ronald G. Sherrill, Tomokazu Yoshinaga, Masanori Kobayashi, Chiaki Wakasa-Morimoto, Shigeru Miki, Koichiro Nakahara, Takeshi Noshi, Akihiko Sato, and Tamio Fujiwara

The Naphthyridinone GSK364735 Is a Novel, Potent Human Immunodeficiency Virus Type 1 Integrase Inhibitor and Antiretroviral
Antimicrob. Agents Chemother. 2008 52: 1899. [Full Text] [PDF] [Reprints and Permissions]  

Zhiyong Zhou, Sean M. Griffing, Alexandre Macedo de Oliveira, Andrea M. McCollum, Wilmer Marquino Quezada, Nancy Arrospide, Ananias A. Escalante, and Venkatachalam Udhayakumar

Decline in Sulfadoxine-Pyrimethamine-Resistant Alleles after Change in Drug Policy in the Amazon Region of Peru
Antimicrob. Agents Chemother. 2008 52: 1900. [Full Text] [PDF] [Reprints and Permissions]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.